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Cysteine Proteases of Pathogenic Organisms Cysteine Proteases of Pathogenic Organisms
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SYSNO ASEP 0364747 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis Author(s) Kašný, M. (CZ)
Mikeš, L. (CZ)
Dolečková, K. (CZ)
Hampl, V. (CZ)
Dvořák, Jan (BC-A)
Novotný, M. (CZ)
Horák, P. (CZ)Source Title Cysteine Proteases of Pathogenic Organisms Cysteine Proteases of Pathogenic Organisms. - BERLIN : SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197, 2011 / Robinson M.D. ; Dalton J.P. - ISSN 0065-2598 - ISBN 978-1-4419-8413-5 Pages s. 136-154 Number of pages 19 s. Number of pages 222 Language eng - English Country DE - Germany Keywords Trichobilharzia ; trematode ; Schistosoma ; Fasciola ; peptidase ; cercarial elastase ; cathepsin ; hydrolysis ; blood digestion ; tissue migration ; biochemical characterization ; phylogeny ; function Subject RIV GJ - Animal Vermins ; Diseases, Veterinary Medicine CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000289378600009 DOI 10.1007/978-1-4419-8414-2 Annotation Trichobilharzia regenti and T. szidati are schistosomes that infect birds. Although T. regenti/T. szidati can only complete their life cycle in specific bird hosts, their larvae -cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts. Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host. These enzymes are indispensable bio catalysts in a number of basal biological processes and host parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
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