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Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells

SYSNO ASEP	0364720
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells
Author(s)	Vagnerová, Karla (FGU-C)_{RID, ORCID} Loukotová, Jana (FGU-C) Ergang, Peter (FGU-C)_{RID, ORCID} Musílková, Jana (FGU-C)_{RID, ORCID} Mikšík, Ivan (FGU-C)_{RID, ORCID, SAI} Pácha, Jiří (FGU-C)_{RID, ORCID}
Source Title	Steroids. - : Elsevier - ISSN 0039-128X Roč. 76, č. 6 (2011), s. 577-581
Number of pages	5 s.
Language	eng - English
Country	US - United States
Keywords	11beta-hydroxysteroid dehydrogenase ; thiazolidinediones
Subject RIV	ED - Physiology
R&D Projects	GAP303/10/0969 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000290828400008
DOI	10.1016/j.steroids.2011.02.008
Annotation	The study demonstrates that activation of PPARgamma in vascular smooth muscle cells up-regulates vascular 11HSD1and thus reactivates 11-oxo metabolites to biologically active glucocorticoids. The data provide one of the possible explanations for PPARgamma-agonist’s effects on the cardiovascular system
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2012

Number of the records: 1