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Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling
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SYSNO ASEP 0364583 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling Author(s) Charles, C. (FR)
Hovořáková, Mária (UEM-P) RID
Ahn, Y. (US)
Lyons, D. B. (US)
Marangoni, P. (FR)
Churavá, Svatava (UEM-P)
Biehs, B. (US)
Jheon, A. (US)
Lesot, H. (FR)
Balooch, G. (US)
Krumlauf, R. (US)
Viriot, L. (FR)
Peterková, Renata (UEM-P) RID
Klein, O. D. (US)Source Title Development. - : Company of Biologists - ISSN 0950-1991
Roč. 138, č. 18 (2011), s. 4063-4073Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords FGF signaling ; Sprouty genes ; Incisor Subject RIV EA - Cell Biology R&D Projects GA304/09/1579 GA ČR - Czech Science Foundation (CSF) GA304/07/0223 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000294156000021 EID SCOPUS 80051933992 DOI 10.1242/dev.069195 Annotation In Sprouty loss of function mutants, splitting of gene expression domains and reduced apoptosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell-containing regions. The changes in Sprouty gene dosage led to a graded change in incisor number, with progressive decreases in Sprouty dosage leading to increasing numbers of teeth. The independent development of two incisors in mutants with large decreases in Sprouty dosage mimicked the likely condition of rodent ancestors. Our findings indicate that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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