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Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study
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SYSNO ASEP 0364530 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study Author(s) Čeřovský, Václav (UOCHB-X) RID, ORCID
Slaninová, Jiřina (UOCHB-X)
Fučík, Vladimír (UOCHB-X) RID
Monincová, Lenka (UOCHB-X)
Bednárová, Lucie (UOCHB-X) RID, ORCID
Maloň, Petr (UOCHB-X)
Štokrová, Jitka (UOCHB-X)Number of authors 7 Source Title Chembiochem. - : Wiley - ISSN 1439-4227
Roč. 12, č. 9 (2011), s. 1352-1361Number of pages 10 s. Language eng - English Country DE - Germany Keywords antimicrobial peptide ; disulfide bridge ; lucifensin ; solid phase synthesis Subject RIV CC - Organic Chemistry R&D Projects GA203/08/0536 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000292096100011 DOI 10.1002/cbic.201100066 Annotation Lucifensin, a novel insect defensin of medicinal maggots identified recently in our laboratory, is 40 amino acid residues and three intramolecular bridges peptide. Oxidative folding of linear lucifensin precursor prepared by solid phase peptide synthesis resulted in a peptide with a pattern of disulfide bridges identical to that of native lucifensin. Synthetic lucifensin was active against Gram-positive bacteria and was not hemolytic. The presence of disulfide bridges and the N-terminal part of its molecule for the structure and antimicrobial activity is essential. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2012
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