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The inhibition of fat cell proliferation by fatty acids in dietary obese mice

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    SYSNO ASEP0364484
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleThe inhibition of fat cell proliferation by fatty acids in dietary obese mice
    Author(s) Hensler, Michal (FGU-C)
    Bardová, Kristina (FGU-C) RID
    Macek Jílková, Zuzana (FGU-C)
    Wahli, W. (CH)
    Meztger, D. (FR)
    Chambon, P. (FR)
    Kopecký, Jan (FGU-C) RID
    Flachs, Pavel (FGU-C) RID
    Source TitleLipids in Health and Disease - ISSN 1476-511X
    Roč. 10, - (2011), s. 128
    Number of pages7 s.
    Languageeng - English
    CountryGB - United Kingdom
    KeywordsDHA and EPA ; fish oil ; fat cell turnover
    Subject RIVFB - Endocrinology, Diabetology, Metabolism, Nutrition
    R&D ProjectsGAP301/11/0226 GA ČR - Czech Science Foundation (CSF)
    GD305/08/H037 GA ČR - Czech Science Foundation (CSF)
    CEZAV0Z50110509 - FGU-C (2005-2011)
    UT WOS000294338000001
    DOI10.1186/1476-511X-10-128
    AnnotationA model of inducible and reversible lipoatrophy (aP2-Cre-ERT2 PPARγL2/L2 mice) was used, in which the death of mature adipocytes could be achieved by a selective ablation of peroxisome proliferator-activated receptor γ in response to i.p. injection of tamoxifen. The results document that dietary LC n-3 PUFA could decrease adiposity in obese mice by a mechanism, which depends on counteraction of both, differentiation and proliferation of adipose cells. These results also support the notion that adiposity is closely linked to the control of fat cell turnover and that mechanisms could exist, which control fat cell proliferation independent of energy balance
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Year of Publishing2012