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The inhibition of fat cell proliferation by fatty acids in dietary obese mice
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SYSNO ASEP 0364484 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The inhibition of fat cell proliferation by fatty acids in dietary obese mice Author(s) Hensler, Michal (FGU-C)
Bardová, Kristina (FGU-C) RID, ORCID, SAI
Macek Jílková, Zuzana (FGU-C)
Wahli, W. (CH)
Meztger, D. (FR)
Chambon, P. (FR)
Kopecký, Jan (FGU-C) RID, ORCID
Flachs, Pavel (FGU-C) RIDSource Title Lipids in Health and Disease
Roč. 10, - (2011), s. 128Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords DHA and EPA ; fish oil ; fat cell turnover Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects GAP301/11/0226 GA ČR - Czech Science Foundation (CSF) GD305/08/H037 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000294338000001 DOI 10.1186/1476-511X-10-128 Annotation A model of inducible and reversible lipoatrophy (aP2-Cre-ERT2 PPARγL2/L2 mice) was used, in which the death of mature adipocytes could be achieved by a selective ablation of peroxisome proliferator-activated receptor γ in response to i.p. injection of tamoxifen. The results document that dietary LC n-3 PUFA could decrease adiposity in obese mice by a mechanism, which depends on counteraction of both, differentiation and proliferation of adipose cells. These results also support the notion that adiposity is closely linked to the control of fat cell turnover and that mechanisms could exist, which control fat cell proliferation independent of energy balance Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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