Number of the records: 1

Biological properties of prolactin-releasing peptide analogs with a modified aromatic ring of a C-terminal phenylalanine amide

SYSNO ASEP	0364368
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Biological properties of prolactin-releasing peptide analogs with a modified aromatic ring of a C-terminal phenylalanine amide
Author(s)	Maletínská, Lenka (UOCHB-X)_{RID, ORCID} Špolcová, Andrea (UOCHB-X)_{RID, ORCID} Maixnerová, Jana (UOCHB-X) Blechová, Miroslava (UOCHB-X) Železná, Blanka (UOCHB-X)_{RID, ORCID}
Number of authors	5
Source Title	Peptides. - : Elsevier - ISSN 0196-9781 Roč. 32, č. 9 (2011), s. 1887-1892
Number of pages	6 s.
Language	eng - English
Country	US - United States
Keywords	pituitary cells ; PrRP analogs ; food intake
Subject RIV	CC - Organic Chemistry
R&D Projects	GAP303/10/1368 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000295767400015
DOI	10.1016/j.peptides.2011.08.011
Annotation	In the present study, eight analogs of PrRP20 with C-terminal Phe amide modified with a bulky side chain or a halogenated aromatic ring revealed high binding potency, activation of mitogen-activated protein kinase/extracellular-regulated kinase (MAPK/ERK1/2) and cAMP response element-binding protein (CREB) and prolactin release in RC-4B/C cells. In particular, [PheNO231]PrRP20, [1-Nal31]PrRP20, [2-Nal31]PrRP20 and [Tyr31]PrRP20 showed not only in vitro effects comparable or higher than those of PrRP20, but also a very significant and long-lasting anorexigenic effect after central administration in fasted mice. The design of potent and long-lasting PrRP analogs with selective anorexigenic properties promise to contribute to the study of food intake disorders.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1