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Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery

SYSNO ASEP	0364301
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery
Author(s)	Líšková, Silvia (FGU-C) Petrová, M. (SK) Karen, Petr (FGU-C) Kuneš, Jaroslav (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI}
Source Title	European Journal of Pharmacology. - : Elsevier - ISSN 0014-2999 Roč. 667, 1-3 (2011), s. 265-270
Number of pages	6 s.
Language	eng - English
Country	NL - Netherlands
Keywords	EDCF ; SHR ; norepinephrine ; L-NNA ; indomethacin
Subject RIV	FA - Cardiovascular Diseases incl. Cardiotharic Surgery
R&D Projects	GA305/09/0336 GA ČR - Czech Science Foundation (CSF)
	IAA500110902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000295056800038
DOI	10.1016/j.ejphar.2011.05.031
Annotation	Endothelium-dependent contraction elicited by high concentrations of acetylcholine was described in hypertensive as well as in aged normotensive rats. The contribution of endothelium-derived constricting factor (EDCF) to norepinephrine-induced contraction is still unknown. We aimed to compare EDCF participation to norepinephrine-induced arterial contraction in spontaneously hypertensive rats (SHR) and aged normotensive Wistar-Kyoto (WKY) rats. We conclude that EDCF contribution to norepinephrine-induced contraction of conduit arteries is similarly enhanced in adult hypertensive and aged normotensive rats
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2012

Number of the records: 1