Number of the records: 1

Altered neural and vascular mechanisms in hypertension

SYSNO ASEP	0364294
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Altered neural and vascular mechanisms in hypertension
Author(s)	Pintérová, Mária (FGU-C) Kuneš, Jaroslav (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI}
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 60, č. 3 (2011), s. 381-402
Number of pages	22 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	adrenoceptors ; G proteins ; L-type voltage-dependent calcium channels ; potassium channels ; RhoA/Rho kinase ; genetic hypertension
Subject RIV	FA - Cardiovascular Diseases incl. Cardiotharic Surgery
R&D Projects	GA305/09/0336 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000293138600002
Annotation	This review is focused on two major antagonistic players in the regulation of blood pressure, i.e. sympathetic nervous system (by stimulation of adrenoceptors coupled to stimulatory and inhibitory G proteins) and nitric oxide (by cGMP signaling pathway), elicit their actions via the control of calcium influx through L-VDCC. However, L-type calcium current can also be regulated by the changes in membrane potential elicited by the activation of potassium channels, the impaired function of which was detected in hypertensive animals. The dominant role of enhanced calcium influx in the pathogenesis of high blood pressure of genetically hypertensive animals is confirmed not only by therapeutic efficacy of calcium antagonists but especially by the absence of hypertension in animals in which L-type calcium current was diminished by pertussis toxin-induced inactivation of inhibitory G proteins
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2012

Number of the records: 1