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DNA Replication-Current Advances

SYSNO ASEP	0364291
Document Type	M - Monograph Chapter
R&D Document Type	Monograph Chapter
Title	Telomore maintenance on organisms without telomerase
Author(s)	Mason, J. M. (US) Reddy, H. M. (US) Čapková Frydrychová, Radmila (BC-A)_{RID, ORCID}
Number of authors	3
Source Title	DNA Replication-Current Advances. - Rijeka : InTech, 2011 / Seligmann Herve - ISBN 978-953-307-593-8
Pages	s. 323-346
Number of pages	24 s.
Number of copy	350
Number of pages	694
Language	eng - English
Country	HR - Croatia
Keywords	telomere
Subject RIV	EB - Genetics ; Molecular Biology
CEZ	AV0Z50070508 - ENTU-I, BC-A (2005-2011)
Annotation	Most eukaryotes elongate chromosome ends with telomerase that repeatedly adds copies of the short telomeric DNA sequence to the chromosome end. While there is strict conservation of telomeric sequence repeat in most species, the repeat unit has changed over evolutionary time. Lack of the predominant telomeric sequence in a species does not, however, signify that telomerase-generated terminal sequences are missing. Conversely, the presence of a canonical telomeric sequence does not necessarily indicate telomerase as a telomere maintenance mechanism. Although telomerase may have been the mechanism of telomere maintenance of the last common eukaryotic ancestor, it is not the only mechanism used to maintain chromosome length. Telomerase has been lost a few times in the evolution of plants and animals. During insect evolution, for example, telomerase has been lost at least six times. Here, we discuss telomere maintenance mechanisms that replaced telomerase in telomere length maintenance.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2012

Number of the records: 1