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Genetic control of resistance to Trypanosoma brucei brucei infection in mice
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SYSNO ASEP 0363620 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genetic control of resistance to Trypanosoma brucei brucei infection in mice Author(s) Šíma, Matyáš (UMG-J) ORCID
Havelková, Helena (UMG-J)
Quan, L. (US)
Svobodová, M. (CZ)
Jarošíková, T. (CZ)
Vojtíšková, Jarmila (UMG-J)
Stassen, A. P. M. (NL)
Demant, P. (US)
Lipoldová, Marie (UMG-J) RIDSource Title PLoS Neglected Tropical Diseases. - : Public Library of Science - ISSN 1935-2735
Roč. 5, č. 6 (2011), e1173Number of pages 12 s. Language eng - English Country US - United States Keywords Trypanosoma brucei brucei ; mouse recombinant congenic strains ; Tbbr Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500520606 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000292139600018 DOI 10.1371/journal.pntd.0001173 Annotation Trypanosoma brucei are extracellular protozoa transmitted to mammalian host by the tsetse fly. Analysis of genes affecting host's resistance to infection can reveal critical aspects of host-parasite interactions. T. b. brucei infects many animal species including livestock. Mouse strains differ greatly in susceptibility to T. b. brucei. However, genes controlling susceptibility to this parasite have not been mapped. We analyzed the genetic control of survival after T. b. brucei infection using CcS/Dem recombinant congenic strains, each of which contains a different random set of 12.5% genes of their donor parental strain STS/A on the BALB/c genetic background. The RC strain CcS-11 is even more susceptible to parasites than BALB/c or STS/A. In F2 hybrids between BALB/c and CcS-11 we detected and mapped four loci, Tbbr1-4 (Trypanosoma brucei brucei response 1–4), that control survival after T. b. brucei infection. Tbbr2 was precision mapped to a segment of 2.15Mb that contains 26 genes. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2012
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