Number of the records: 1

Biomarkers of exposure and effect – interpretation for human risk

SYSNO ASEP	0363581
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Biomarkers of exposure and effect – interpretation for human risk
Author(s)	Šrám, Radim (UEM-P)_RID Binková, B. (CZ) Beskid, Olena (UEM-P) Milcová, Alena (UEM-P) Rössner, P. (CZ) Rössner ml., Pavel (UEM-P)_{RID, ORCID} Rössnerová, Andrea (UEM-P)_RID Solanský, I. (CZ) Topinka, Jan (UEM-P)_{RID, ORCID}
Source Title	Air Quality, Atmosphere and Health (AQAH) - ISSN 1873-9318 Roč. 4, č. 3 (2011), s. 161-167
Number of pages	9 s.
Language	eng - English
Country	NL - Netherlands
Keywords	personal monitoring ; benzo[a]pyrene ; carcinogenic polycyclic aromatic hydrocarbons
Subject RIV	DN - Health Impact of the Environment Quality
R&D Projects	SL/5/160/05 GA MŽP - Ministry of Environment (MŽP)
	SP/1B3/8/08 GA MŽP - Ministry of Environment (MŽP)
CEZ	AV0Z50390512 - UEM-P (2005-2011)
UT WOS	000309479900002
EID SCOPUS	80051694260
DOI	10.1007/s11869-011-0133-8
Annotation	The effect of exposure to carcinogenic PAHs adsorbed onto respirable air particles on DNA adducts and chromosomal aberrations was repeatedly studied in groups of policemen and bus drivers from Prague, Czech Republic. Personal exposure was evaluated using personal samplers during working shifts. DNA adducts were analyzed in lymphocytes by the 32P-postlabeling assay and chromosomal aberrations by conventional cytogenetic analysis and by fluorescent in situ hybridization (FISH). The studies suggest that the environmental exposure of nonsmokers to concentrations higher than 1 ng B[a]P/m3 represents a risk to DNA damage, as indicated by an increase in DNA adducts and in the genomic frequency of translocations determined by FISH.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2012

Number of the records: 1