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Optimization of catalyst-solvent system for preparation of alpha-5,6-dihydro-5-aza-2'-deoxy-[6-3H]-cytidine
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SYSNO ASEP 0363304 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Optimization of catalyst-solvent system for preparation of alpha-5,6-dihydro-5-aza-2'-deoxy-[6-3H]-cytidine Author(s) Elbert, Tomáš (UOCHB-X) RID, ORCID Number of authors 1 Source Title Journal of Labelled Compounds and Radiopharmaceuticals. - : Wiley - ISSN 0362-4803
Roč. 54, č. 5 (2011), s. 285-285Number of pages 1 s. Action Workshop of the International Isotope Society - Central European Division. The Synthesis and Applications of Isotopes and Isotopically Labelled Compounds /17./ Event date 23.09.2010-24.09.2010 VEvent location Bad Soden Country DE - Germany Event type EUR Language eng - English Country GB - United Kingdom Keywords tritium ; labelled compounds ; alfa-5,6-dihydro-5-aza-2'-deoxy-cytidine Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) Annotation The optimization of catalyst-solvent system for the tritiation of alfa-5-aza-2'-deoxy-cytidine was targeted on the shortening of the reaction time and on the suppression of the exchange solution – gas. The combination of Adams catalyst (platinum dioxide) and dimethylformamide gave better than 90% conversion in 75 minutes and about 50% enrichment by deuterium in model experiments. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2012
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