Number of the records: 1

The Peptidic GHS-R antagonist [D-Lys3]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity

SYSNO ASEP	0363114
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The Peptidic GHS-R antagonist [D-Lys3]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity
Author(s)	Maletínská, Lenka (UOCHB-X)_{RID, ORCID} Matyšková, Resha (UOCHB-X) Maixnerová, Jana (UOCHB-X) Sýkora, D. (CZ) Pýchová, Miroslava (UOCHB-X) Špolcová, Andrea (UOCHB-X)_{RID, ORCID} Blechová, Miroslava (UOCHB-X) Drápalová, J. (CZ) Lacinová, Z. (CZ) Haluzík, M. (CZ) Železná, Blanka (UOCHB-X)_{RID, ORCID}
Number of authors	11
Source Title	Molecular and Cellular Endocrinology. - : Elsevier - ISSN 0303-7207 Roč. 343, 1/2 (2011), s. 55-62
Number of pages	8 s.
Language	eng - English
Country	IE - Ireland
Keywords	GHS-R ; [D-Lys3]GHRP-6 ; ovariectomized obese mice
Subject RIV	CE - Biochemistry
R&D Projects	GA303/09/0744 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000295349200007
DOI	10.1016/j.mce.2011.06.006
Annotation	Ghrelin receptor antagonist [D-Lys3]GHRP-6 after seven days of subcutaneous treatment markedly decreased food intake in OVX mice fed both HF and standard diets; furthermore, it reduced body weight and blood glucose, insulin and leptin, and increased beta-hydroxybutyrate level and uncoupling-protein-1 mRNA in brown adipose tissue. Pair-feeding revealed that effect of [D-Lys3]GHRP-6 was primary anorexigenic. Estrogen supplementation reduced anorexigenic effects of [D-Lys3]GHRP-6. OVX [D-Lys3]GHRP-6 treatment in mice on HF diet resulted in markedly increased circulating level and liver expression of a major metabolic regulator, fibroblast growth factor 21. Our data suggest that ghrelin antagonists could be especially beneficial in individuals with common obesity combined with estrogen deficiency.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1