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Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition

SYSNO ASEP	0363004
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition
Author(s)	Kverka, Miloslav (MBU-M)_{RID, ORCID} Zákostelská, Zuzana (MBU-M)_RID Klimešová, Klára (MBU-M)_RID Sokol, Dan (MBU-M) Hudcovic, Tomáš (MBU-M)_{RID, ORCID} Hrnčíř, Tomáš (MBU-M)_{RID, ORCID} Rossmann, Pavel (MBU-M) Mrázek, Jakub (UZFG-Y)_{RID, ORCID} Kopečný, Jan (UZFG-Y)_{RID, ORCID} Verdu, E. (CA) Tlaskalová-Hogenová, Helena (MBU-M)_{RID, ORCID}
Source Title	Clinical and Experimental Immunology. - : Oxford University Press - ISSN 0009-9104 Roč. 163, č. 2 (2011), s. 250-259
Number of pages	10 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	animal models ; cytokines/interleukins ; DSS colitis
Subject RIV	EE - Microbiology, Virology
R&D Projects	KJB500200904 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	1QS500200572 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	IAA5020205 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GD310/08/H077 GA ČR - Czech Science Foundation (CSF)
	GA303/08/0367 GA ČR - Czech Science Foundation (CSF)
	GA305/08/0535 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
	AV0Z50450515 - UZFG-Y (2005-2011)
UT WOS	000285922400013
DOI	10.1111/j.1365-2249.2010.04286.x
Annotation	Commensal bacteria have been shown to modulate the host mucosal immune system. Here, we report that oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies and stabilized the intestinal microbial ecology
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2012

Number of the records: 1