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Mitochondrially targeted anti-cancer agents
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SYSNO ASEP 0361635 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mitochondrially targeted anti-cancer agents Author(s) Biasutto, L. (IT)
Dong, L.A. (AU)
Zoratti, M. (IT)
Neužil, Jiří (BTO-N) RIDSource Title Mitochondrion. - : Elsevier - ISSN 1567-7249
Roč. 10, č. 6 (2010), s. 670-681Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords Mitochondrial targeting ; pro-oxidant effect ; reactive oxygen species Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000284660000011 DOI 10.1016/j.mito.2010.06.004 Annotation Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently,a considerable challenge.Mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans,have been a recent focus of research.Of these compounds, many are hydrophobic agents that associate with various subcellular organelles.Modification of such structures with mitochondria-targeting moieties,for example tagging them with lipophilic cations,would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. We propose that mitochondrial targeting, in particular where the agent associates directly with the target,results in more specific and efficient anti-cancer drugs of potential high clinical relevance Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2012
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