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Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis
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SYSNO ASEP 0361620 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis Author(s) Kverka, Miloslav (MBU-M) RID, ORCID
Rossmann, Pavel (MBU-M)
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCID
Klimešová, Klára (MBU-M) RID
Jharap, B. (NL)
de Boer, N. (NL)
Vos, R. M. (NL)
van Bodegraven, A.A. (NL)
Lukáš, M. (CZ)
Mulder, Ch.J. (NL)Source Title BMC Gastroenterology
Roč. 11, č. 1 (2011), s. 1-9Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords INFLAMMATORY-BOWEL-DISEASE ; NODULAR REGENERATIVE HYPERPLASIA ; LOW-DOSE 6-THIOGUANINE Subject RIV EC - Immunology R&D Projects KJB500200904 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GD310/08/H077 GA ČR - Czech Science Foundation (CSF) 2B06155 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000290792100001 DOI 10.1186/1471-230X-11-47 Annotation Background: Oral thiopurines are effective and widely used in treatment of inflammatory bowel disease (IBD) in humans, although their use is limited due the development of adverse events. Here, we examine the efficacy and toxicity of oral treatment with 6-tioguanine (6-TG) and azathioprine (AZA) in a murine model of IBD Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2012
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