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Spontaneous in vitro IL-6 production in various intestinal segments in patients with inflammatory bowel diseases
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SYSNO ASEP 0361618 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Spontaneous in vitro IL-6 production in various intestinal segments in patients with inflammatory bowel diseases Author(s) Drastich, P. (CZ)
Frolová-Břízová, Lenka (MBU-M)
Zanvit, P. (CZ)
Špičák, J. (CZ)
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCIDSource Title Folia Microbiologica. - : Springer - ISSN 0015-5632
Roč. 56, č. 3 (2011), 185-190Number of pages 6 s. Language eng - English Country CZ - Czech Republic Keywords NECROSIS-FACTOR-ALPHA ; ULCERATIVE-COLITIS ; CROHNS-DISEASE Subject RIV EC - Immunology R&D Projects 1QS500200572 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA305/08/0535 GA ČR - Czech Science Foundation (CSF) GD310/08/H077 GA ČR - Czech Science Foundation (CSF) 2B06155 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000292564200001 DOI 10.1007/s12223-011-0018-0 Annotation Interleukin-6 (IL-6) plays an important role in regulation of intestinal inflammatory processes in inflammatory bowel disease (IBD). The levels of IL-6 in media from cultured biopsy samples were determined by ELISA in 14 Crohn’s disease (CD) patients, 17 patients with ulcerative colitis (UC), and 24 healthy controls in terminal ileum, cecum, and rectum. Results were confirmed by measuring mRNA expression in selected patients. In CD patients, there were increased levels of IL-6 (expressed in picograms per milligram of biopsy tissue mass) in terminal ileum compared with controls Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2012
Number of the records: 1