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Gliadin fragments promote migration of dendritic cells
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SYSNO ASEP 0361617 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Gliadin fragments promote migration of dendritic cells Author(s) Chládková, Barbara (MBU-M) RID
Kamanová, Jana (MBU-M) ORCID, RID
Palová-Jelínková, Lenka (MBU-M) RID
Cinová, Jana (MBU-M)
Šebo, Peter (MBU-M) RID, ORCID
Tučková, Ludmila (MBU-M) RIDSource Title Journal of Cellular and Molecular Medicine. - : Wiley - ISSN 1582-1838
Roč. 15, č. 4 (2011), 938-948Number of pages 11 s. Language eng - English Country US - United States Keywords celiac disease ; gliadin ; dendritic cell Subject RIV EC - Immunology R&D Projects GA310/07/0414 GA ČR - Czech Science Foundation (CSF) GD310/08/H077 GA ČR - Czech Science Foundation (CSF) GA310/08/0447 GA ČR - Czech Science Foundation (CSF) IAA500200801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA500200914 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000290312700019 DOI 10.1111/j.1582-4934.2010.01066.x Annotation This study provides a new insight into pathogenic features of gliadin fragments by demonstrating their ability to promote DC migration, which is a prerequisite for efficient priming of naive T cells, contributing to celiac disease pathology. In genetically predisposed individuals, ingestion of wheat gliadin provokes a T-cell-mediated enteropathy, celiac disease. Gliadin fragments were previously reported to induce phenotypic maturation and Th1 cytokine production by human dendritic cells (DCs) and to boost their capacity to stimulate allogeneic T cells. Here, we monitor the effects of gliadin on migratory capacities of DCs. Using transwell assays, we show that gliadin peptic digest stimulates migration of human DCs and their chemotactic responsiveness to the lymph node-homing chemokines CCL19 and CCL21 Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2012
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