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Similarity of fine specificity of IgA-gliadin antibodies between patients with celiac disease and humanized α 1KI mice
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SYSNO ASEP 0361616 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Similarity of fine specificity of IgA-gliadin antibodies between patients with celiac disease and humanized α 1KI mice Author(s) Sánchez, Daniel (MBU-M) RID
Champier, G. (FR)
Cuvillier, A. (FR)
Cogné, M. (FR)
Pekáriková, Aneta (MBU-M)
Tlaskalová, Helena (MBU-M) RID
Hoffmanová, I. (CZ)
Drastich, P. (CZ)
Mothes, T. (DE)
Tučková, Ludmila (MBU-M) RIDSource Title Journal of Agricultural and Food Chemistry. - : American Chemical Society - ISSN 0021-8561
Roč. 59, č. 7 (2011), 3092-3100Number of pages 9 s. Language eng - English Country US - United States Keywords alpha 1KI mouse ; IgA antibodies ; celiac disease Subject RIV EC - Immunology R&D Projects IAA500200709 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA310/07/0414 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000289050400047 DOI 10.1021/jf1044519 Annotation Gliadins, and primarily a-gliadins containing several sequences such as aa 31-49, aa 56-88 (33-mer), aa 57-68, and aa 69-82, are critical in the induction of immune response or toxic reaction leading to the development of celiac disease (CLD). The role of IgA anti-gliadin antibodies (IgA AGA) is unknown. To this end, we prepared several humanized monoclonal IgA AGA using transgenic α1KI mice. Employing Pepscan with overlapping decapeptides of a-gliadin we observed a robust similarity between the specificity of humanized mouse monoclonal IgA AGA and IgA AGA from patients with florid CLD Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2012
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