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Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level

SYSNO ASEP	0361510
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level
Author(s)	Nosáľ, R. (SK) Perečko, T. (SK) Jančinová, V. (SK) Drábiková, K. (SK) Harmatha, Juraj (UOCHB-X)_{RID, ORCID} Sviteková, K. (SK)
Number of authors	6
Source Title	Pharmacological Reports. - : Springer - ISSN 1734-1140 Roč. 63, č. 3 (2011), s. 790-798
Number of pages	9 s.
Language	eng - English
Country	PL - Poland
Keywords	neutrophils ; N-feruloylserotonin ; extracellular and intracellular chemiluminescence
Subject RIV	CC - Organic Chemistry
R&D Projects	GA203/07/1227 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000295203500019
DOI	10.1016/S1734-1140(11)70591-6
Annotation	N-feruloylserotonin (N-f-5HT) isomers, isolated from seeds of Leuzea carthamoides, inhibited dose-dependent oxidative burst in human whole blood and isolated neutrophils in vitro, which were measured by luminol-and/or isoluminol-enhanced chemiluminescence. The results suggest that N-f-5HT isomers are an effective, naturally occurring substances with a potent pharmacological effect on the oxidative burst of human neutrophils.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1