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Electrostatic Interaction of Negatively Charged Core–Shell Nanoparticles with Antitumoral Cationic Platinum-Based Complexes
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SYSNO ASEP 0361506 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Electrostatic Interaction of Negatively Charged Core–Shell Nanoparticles with Antitumoral Cationic Platinum-Based Complexes Author(s) Gál, Miroslav (UFCH-W)
Híveš, J. (SK)
Laus, M. (IT)
Sparnacci, K. (IT)
Ravera, M. (IT)
Gabano, E. (IT)
Osella, D. (IT)Source Title European Journal of Inorganic Chemistry. - : Wiley - ISSN 1434-1948
-, č. 22 (2011), s. 3289-3294Number of pages 6 s. Language eng - English Country DE - Germany Keywords platinum ; Antitumor agents ; nanoparticles Subject RIV CG - Electrochemistry R&D Projects GP203/09/P502 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000293299100003 DOI 10.1002/ejic.201100454 Annotation We report herein on the interaction between two cationic antiproliferative platinum compounds [namely cis-[PtCl(NH3)2(py)]Cl (1) and trans,trans-[(NH3)2Pt{NH2(CH2)4NH2}PtCl(NH3)2](Cl)2 (2)] and novel poly(methyl methacrylate) core–shell nanoparticles (MS) bearing anionic SO3– arms, studied to determine whether such particles might serve as drug carriers for Pt drugs. Electrostatic forces hold together the resulting adducts such that in the presence of higher concentrations of other cations the Pt drug should be released quickly and easily. As expected from their electric charges, we found that the formation constant of the MS-2 adduct is significantly higher than that of MS-1. Moreover, the stability of both adducts depends on the ionic strength and surface charge density of competing cations in the medium. The stability of the conjugates and the consequent retention and release of the drug from the nanoparticles will thus depend on both blood and extracellular fluid composition. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2012
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