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Radiation damage to DNA-protein complexes
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SYSNO ASEP 0361498 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Radiation damage to DNA-protein complexes Author(s) Spotheim-Maurizot, M. (FR)
Davídková, Marie (UJF-V) RID, ORCID, SAISource Title Journal of Physics: Conference Series. - : Institute of Physics Publishing - ISSN 1742-6588
Roč. 261, zima (2011), s. 1-10Number of pages 10 s. Action COST Chemistry CM0603-MELUSYN Joint Meeting Damages Induced in Biomolecules by Low and High Energy Radiations Event date 09.03.2010-12.03.2010 VEvent location Paříž Country FR - France Event type WRD Language eng - English Country GB - United Kingdom Keywords radiolysis ; molecular-dynamics simulation ; hydroxyl radical attack ; induced strand breakage Subject RIV BO - Biophysics R&D Projects IAA1048103 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KJB4048401 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1P05OC085 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OC09012 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAB1048901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000291672100010 DOI 10.1088/1742-6596/261/1/012010 Annotation We review here the advances in understanding the effects of ionizing radiations on DNA, proteins and their complexes. A model of simulation of the reaction of these radicals with the macromolecules (called RADACK) was developed and was used for calculating the probabilities of damage of each constituent of DNA or proteins (nucleotide or amino-acid). The calculations allowed to draw conclusions from electrophoresis, mutagenesis, spectroscopic (fluorescence, circular dichroism) and mass spectrometry experiments. Thus we have shown that the extent and location of the lesions are strongly dependent on the 3D structure of the macromolecules, which in turns is modulated by their sequence and by the binding of some ligands. Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2012
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