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Polysaccharides in Medicinal and Pharmaceutical Applications
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SYSNO ASEP 0361112 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Carbohydrate-Containing Dendrimers in Biomedical Applications Author(s) Šebestík, Jaroslav (UOCHB-X) RID, ORCID
Reiniš, Milan (UMG-J) RID
Ježek, Jan (UOCHB-X) RIDNumber of authors 3 Source Title Polysaccharides in Medicinal and Pharmaceutical Applications. - Shawbury : iSmithers, 2011 / Popa V. - ISBN 978-1-84735-437-2 Pages s. 353-384 Number of pages 13 s. Number of pages 408 Language eng - English Country GB - United Kingdom Keywords dendrimers ; drug delivery ; gene delivery ; glycobiology ; glycoclusters Subject RIV CC - Organic Chemistry R&D Projects GA203/07/1517 GA ČR - Czech Science Foundation (CSF) IAA400550702 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) AV0Z50520514 - UMG-J (2005-2011) Annotation Glycodendrimers are (regularly) branched structures containing carbohydrates. Many of these compounds with various composition and structure are mentioned; as well as, their practical applications spanning from drug and gene deliveries, synthetic vaccines, prevention of pathological processes caused by bacteria and viruses, etc. A dendrimeric state, physicochemical properties of dendrimers, and general consequences are reviewed with emphasis to a cluster effect and multivalency. Two main approaches of glycodendrimer syntheses - convergent and divergent - are described. Since glycopeptide dendrimers suppress lectin-carbohydrate interactions, glycodendrimeric libraries provide potent inhibitors of bacterial adhesion and biofilm formation. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2012
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