Number of the records: 1

The antifungal effect of peptides from hymenoptera venom and their analogs

SYSNO ASEP	0360967
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The antifungal effect of peptides from hymenoptera venom and their analogs
Author(s)	Slaninová, Jiřina (UOCHB-X) Putnová, Helena (UOCHB-X) Borovičková, Lenka (UOCHB-X) Šácha, Pavel (UOCHB-X)_{RID, ORCID} Čeřovský, Václav (UOCHB-X)_{RID, ORCID} Monincová, Lenka (UOCHB-X) Fučík, Vladimír (UOCHB-X)_RID
Number of authors	7
Source Title	Central European Journal of Biology - ISSN 1895-104X Roč. 6, č. 2 (2011), s. 150-159
Number of pages	10 s.
Language	eng - English
Country	PL - Poland
Keywords	antifungal agents ; candida ; fluorescent microscopy ; rhodamine 6G ; fluorescein-labeled peptide
Subject RIV	CC - Organic Chemistry
R&D Projects	GA203/08/0536 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000287457200003
DOI	10.2478/s11535-010-0111-4
Annotation	Minimal inhibitory concentrations (MICs) against different Candida species (C. albicans, C. krusei, C. glabrata, C. tropicalis and C. parapsilosis) of recently isolated, synthesized and characterized antimicrobial alpha-helical amphipathic peptides (12–18 amino acids long) from the venom of hymenoptera (melectin, lasioglossins I, II, and III, halictines I and II) as well as a whole series of synthetic analogs were determined. In the case of the natural peptides they amounted to 4–20 .mu.M (7–40 mg/l). The most active ones were the synthetic analogs all-D-lasioglossin III and KNWKK-Aib-LGK-Aib-IK-Aib-VK-NH2.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1