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Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine
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SYSNO ASEP 0360867 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine Author(s) Biswas, A. (US)
Wilmanski, J. (US)
Forsman, H. (US)
Hrnčíř, Tomáš (MBU-M) RID, ORCID
Hao, L. (US)
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCID
Kobayashi, K. (US)Source Title European Journal of Immunology. - : Wiley - ISSN 0014-2980
Roč. 41, č. 1 (2011), s. 182-194Number of pages 13 s. Language eng - English Country DE - Germany Keywords Caspase-1 ; Colitis ; IL-10 Subject RIV EC - Immunology R&D Projects GP310/09/P182 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000285933000019 DOI 10.1002/eji.201040479 Annotation A healthy intestinal tract is characterized by controlled homeostasis due to the balanced interaction between commensal bacteria and the host mucosal immune system. Human and animal model studies have supported the hypothesis that breakdown of this homeostasis may underlie the pathogenesis of inflammatory bowel diseases. However, it is not well understood how intestinal microflora stimulate the intestinal mucosal immune system and how such activation is regulated Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2012
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