Number of the records: 1

SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors

SYSNO ASEP	0360813
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors
Author(s)	Šála, Michal (UOCHB-X)_{RID, ORCID} De Palma, A. M. (BE) Hřebabecký, Hubert (UOCHB-X)_{RID, ORCID} Dejmek, Milan (UOCHB-X)_{RID, ORCID} Dračínský, Martin (UOCHB-X)_{RID, ORCID} Leyssen, P. (BE) Neyts, J. (BE) Mertlíková-Kaiserová, Helena (UOCHB-X)_{RID, ORCID} Nencka, Radim (UOCHB-X)_{RID, ORCID}
Number of authors	9
Source Title	Bioorganic and Medicinal Chemistry Letters. - : Elsevier - ISSN 0960-894X Roč. 21, č. 14 (2011), s. 4271-4275
Number of pages	5 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	coxsackievirus ; norbornane ; picornaviruses
Subject RIV	CC - Organic Chemistry
R&D Projects	1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GAP303/11/1297 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000292186400033
DOI	10.1016/j.bmcl.2011.05.070
Annotation	Coxsackievirus and related enteroviruses are important human pathogens that cause various diseases with clinical manifestations ranging from trivial flu-like syndromes to dangerous or even fatal diseases such as myocarditis, meningitis and encephalitis. Here, we report on our continuous SAR study focused on 9-(bicyclo[2.2.1]hept-2-yl)-9H-purines as anti-enteroviral inhibitors. The purine moiety was modified at positions 2, 6 and 8. Several analogues inhibited coxsackievirus B3 as well as other enteroviruses at low-micromolar concentrations. The 6-chloropurine derivative was confirmed as the most active compound in this series.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1