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Rapid changes in gene expression: DNA determinants of promoter regulation by the

SYSNO ASEP	0360790
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Rapid changes in gene expression: DNA determinants of promoter regulation by the
Author(s)	Sojka, Luděk (MBU-M) Kouba, Tomáš (MBU-M) Barvík, I. (CZ) Šanderová, Hana (MBU-M)_{RID, ORCID} Maderová, Zdeňka (MBU-M) Jonák, Jiří (MBU-M) Krásný, Libor (MBU-M)_{RID, ORCID}
Source Title	Nucleic Acids Research. - : Oxford University Press - ISSN 0305-1048 Roč. 39, č. 11 (2011), s. 4598-4611
Number of pages	14 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	RIBOSOMAL-RNA TRANSCRIPTION ; ILV-LEU OPERON ; CHAIN AMINO-ACIDS
Subject RIV	EE - Microbiology, Virology
R&D Projects	2B06065 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000291755000013
DOI	10.1093/nar/gkr032
Annotation	In bacteria, rapid changes in gene expression can be achieved by affecting the activity of RNA polymerase with small molecule effectors during transcription initiation. An important small molecule effector is the initiating nucleoside triphosphate (iNTP). At some promoters, an increasing iNTP concentration stimulates promoter activity, while a decreasing concentration has the opposite effect. Ribosomal RNA (rRNA) promoters from Grampositive Bacillus subtilis are regulated by the concentration of their iNTP. Yet, the sequences of these promoters do not emulate the sequence characteristics of [iNTP]-regulated rRNA promoters of Gram-negative Escherichia coli. Here, we identified the 30-promoter region, corresponding to the transcription bubble, as key for B. subtilis rRNA promoter regulation via the concentration of the iNTP
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2012

Number of the records: 1