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Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces
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SYSNO ASEP 0360787 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces Author(s) Rodriguez-Emmenegger, Cesar Adolfo (UMCH-V) RID
Brynda, Eduard (UMCH-V) RID
Riedel, Tomáš (UMCH-V) RID, ORCID
Houska, Milan (UMCH-V) RID
Šubr, Vladimír (UMCH-V) RID, ORCID
Bologna Alles, A. (UY)
Hasan, E. (GB)
Gautrot, J. E. (GB)
Huck, W. T. S. (GB)Source Title Macromolecular Rapid Communications. - : Wiley - ISSN 1022-1336
Roč. 32, č. 13 (2011), s. 952-957Number of pages 6 s. Language eng - English Country DE - Germany Keywords biosensors ; blood plasma ; HPMA Subject RIV CD - Macromolecular Chemistry R&D Projects KAN200670701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000292547100002 DOI 10.1002/marc.201100189 Annotation Ultra-low-fouling poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)) brushes have been synthesized for the first time. Similar to the so far only ultra-low-fouling surface, poly(carboxybetaine acrylamide), the level of blood plasma fouling was below the detection limit of surface plasmon resonance (SPR, 0.03 ng • cm−2) despite being a hydrogen bond donor and displaying a moderate wettability, thus challenging the currently accepted views for the design of antifouling properties. The antifouling properties were preserved even after two years of storage. To demonstrate the potential of poly(HPMA) brushes for the preparation of bioactive ultra-low fouling surfaces a label-free SPR immunosensor for detection of G Streptococcus was prepared. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2012
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