Number of the records: 1
The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions
- 1.
SYSNO ASEP 0360763 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions Author(s) Sedláček, Ondřej (UOCHB-X)
Břehová, Petra (UOCHB-X) RID, ORCID
Pohl, Radek (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)
Janeba, Zlatko (UOCHB-X) RID, ORCIDNumber of authors 5 Source Title Canadian Journal of Chemistry. - : Canadian Science Publishing - ISSN 0008-4042
Roč. 89, č. 4 (2011), s. 488-489Number of pages 11 s. Language eng - English Country CA - Canada Keywords acyclic nucleoside phosphonates ; PMEDAP ; cross-coupling ; antiviral ; antitumor Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000288873200007 DOI 10.1139/V11-001 Annotation The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) analogues was performed from diisopropyl 8-bromo-2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine using Stille, Suzuki-Miyaura, Negishi, and Sonogashira cross-coupling reactions, as well as Pd-catalysed reactions with trialkylaluminiums. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2012
Number of the records: 1