Number of the records: 1

Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short

SYSNO ASEP	0360713
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short
Author(s)	Bojarová, Pavla (MBU-M)_ORCID Křen, Vladimír (MBU-M)_{RID, ORCID}
Source Title	Chimia - ISSN 0009-4293 Roč. 65, 1-2 (2011), 64-70
Number of pages	6 s.
Language	eng - English
Country	CH - Switzerland
Keywords	Carbohydrate ; Enzymatic synthesis ; Glycosidase
Subject RIV	CC - Organic Chemistry
R&D Projects	GP203/09/P024 GA ČR - Czech Science Foundation (CSF)
	LC06010 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	OC09045 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000287981400013
DOI	10.2533/chimia.2011.65
Annotation	Thanks to the stability, good availability, stereoselectivity and broad substrate specificity, oligosacharide synthesis catalyzed by glycosidases represents an elegant way to komplex carbohydrate structures. Two approaches to glycosidase catalysis are presented: i) the use of structurally modified substrates that carry various functional moieties in the molecule, and ii) the design of mutant glycosidases void of hydrolytic activity. Products of glycosidase catalyzed synthesis are applicable in a range of areas such as immunology, therapy of Alzheimer’s or Parkinson’s diseases and the synthesis of neoglycoproteins
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2012

Number of the records: 1