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Tooth-bone morphogenesis during postnatal stages of mouse first molar development
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SYSNO ASEP 0360057 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Tooth-bone morphogenesis during postnatal stages of mouse first molar development Author(s) Lungová, V. (CZ)
Radlanski, R.J. (DE)
Tucker, A. S. (GB)
Renz, H. (DE)
Míšek, Ivan (UZFG-Y)
Matalová, Eva (UZFG-Y) RIDNumber of authors 6 Source Title Journal of Anatomy. - : Wiley - ISSN 0021-8782
Roč. 218, č. 6 (2011), s. 699-716Number of pages 18 s. Language eng - English Country US - United States Keywords apoptosis ; dentition ; development Subject RIV EA - Cell Biology R&D Projects GC524/08/J032 GA ČR - Czech Science Foundation (CSF) NT11420 GA MZd - Ministry of Health (MZ) CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000290176400012 DOI 10.1111/j.1469-7580.2011.01367.x Annotation The first mouse molar (M1) is the most common model for odontogenesis, with research particularly focused on prenatal development. However, the functional dentition forms postnatally, when the histogenesis and morphogenesis of the tooth is completed, the roots form and the tooth physically anchors into the jaw. In this work, M1 was studied from birth to eruption, assessing morphogenesis, proliferation and apoptosis, and correlating these with remodeling of the surrounding bony tissue. The M1 completed crown formation between postnatal (P) days 0-2, and the development of the tooth root was initiated at P4. From P2 until P12, cell proliferation in the dental epithelium reduced and shifted downward to the apical region of the forming root. In contrast, proliferation was maintained or increased in the mesenchymal cells of the dental follicle. At later stages, before tooth eruption (P20), cell proliferation suddenly ceased. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2012
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