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Subspecific origin and haplotype diversity in the laboratory mouse
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SYSNO ASEP 0360034 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Subspecific origin and haplotype diversity in the laboratory mouse Author(s) Yang, H. (US)
Wang, J. R. (US)
Didion, J. P. (US)
Buus, R. J. (US)
Bell, T. A. (US)
Welsh, C. E. (US)
Bonhomme, F. (FR)
Yu, A. H.-T. (TW)
Nachman, M. W. (US)
Piálek, Jaroslav (UBO-W) RID, ORCID, SAI
Tucker, P. (US)
Boursot, P. (FR)
McMillan, L. (US)
Churchill, G. A. (US)
de Villena, F. P. (US)Number of authors 15 Source Title Nature Genetics. - : Nature Publishing Group - ISSN 1061-4036
Roč. 45, č. 7 (2011), s. 648-655Number of pages 10 s. Language eng - English Country US - United States Keywords inbred strains ; house mice ; resource ; genome ; genes ; SNPS Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA206/08/0640 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000292184600008 EID SCOPUS 79959735506 DOI 10.1038/ng.847 Annotation Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild-caught mice from three subspecies of Mus musculus. We show that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly Mus musculus domesticus in origin, and the remainder is mostly of Japanese origin. We generated genome-wide haplotype maps based on identity by descent from fancy mice and show that classical inbred strains have limited and non-randomly distributed genetic diversity. In contrast, wild-derived laboratory strains represent a broad sampling of diversity within M. musculus. Intersubspecific introgression is pervasive in these strains, and contamination by laboratory stocks has played a role in this process. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2012
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