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Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes

SYSNO ASEP	0359971
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes
Author(s)	Vyskočil, V. (CZ) Navrátil, Tomáš (UFCH-W)_{RID, ORCID} Barek, J. (CZ)
Source Title	Sborník přednášek. XXXI. Moderní elektrochemické metody. - Ústí nad Labem : BEST servis, 2011 / Navrátil Tomáš ; Barek J. - ISBN 978-80-254-9634-3
Pages	s. 190-194
Number of pages	5 s.
Action	Moderní elektrochemické metody /31./
Event date	23.05.2011-27.05.2011
VEvent location	Jetřichovice
Country	CZ - Czech Republic
Event type	WRD
Language	eng - English
Country	CZ - Czech Republic
Keywords	creatine ; screen-printed carbon electrodes ; flutamide
Subject RIV	CG - Electrochemistry
R&D Projects	IAA400400806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GAP206/11/1638 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40400503 - UFCH-W (2005-2011)
UT WOS	000304395000042
Annotation	Flutamide, 4-nitro-3-trifluoromethyl-isobutylanilide, is the active component of a synthetic nonsteroidal antiandrogen drug, which is commonly used in the treatment of advanced prostate cancer. In this contribution, optimum conditions have been found vor voltammetric determination of flutamide by DC voltammetry (DCV) and differential pulse voltammetry (DPV) at screen-printed carbon electrodes (SPCEs). Under optimum conditions (Britton-Robinson buffer pH 7.0 - methanol (9:1)), linear calibration curves were measure with limits of quantification 6x10(-7) molL(-1) and 8x10(-7) molL(-1) for DCV at SPCEs, respectively. The newly developed methods were successfully applied to the determination of the drug in pharmaceutical formulation Apo-Flutamide (Eulexin tablets).
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2012

Number of the records: 1