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Age-dependent remodelling of ionotropic signalling in cortical astroglia

SYSNO ASEP	0359954
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Age-dependent remodelling of ionotropic signalling in cortical astroglia
Author(s)	Lalo, U. (GB) Palygin, O. (US) North, R. A. (GB) Verkhratsky, Alexei (UEM-P) Pankratov, Y. (GB)
Source Title	Aging Cell. - : Wiley - ISSN 1474-9718 Roč. 10, č. 3 (2011), s. 392-402
Number of pages	11 s.
Language	eng - English
Country	US - United States
Keywords	astrocytes ; aging ; synaptic transmission
Subject RIV	FH - Neurology
R&D Projects	GA305/08/1384 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50390703 - UEM-P (2007-2013)
UT WOS	000290531900004
EID SCOPUS	79955973304
DOI	10.1111/j.1474-9726.2011.00682.x
Annotation	Here, we demonstrated marked age-dependent changes in ionotropic receptors (AMPA, P2X and NMDA) in astrocytes and their role in GSCs generation. Our results demonstrate that fast synaptic transmission between neurones and astrocytes in neocortex that may be involved in information processing in neuronal-glial networks undergoes remodelling during brain maturation and aging.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2012

Number of the records: 1