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Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat
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SYSNO ASEP 0359902 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat Author(s) Machová-Urdzíková, Lucia (UEM-P) ORCID
Mašínová, Katarína (UEM-P)
Vaněček, Václav (UEM-P)
Růžička, Jiří (UEM-P)
Šedý, Jiří (UEM-P)
Syková, Eva (UEM-P) RID
Jendelová, Pavla (UEM-P) RID, ORCIDSource Title Cytotherapy. - : Elsevier - ISSN 1465-3249
Roč. 13, č. 9 (2011), s. 1090-1104Number of pages 15 s. Language eng - English Country GB - United Kingdom Keywords axonal sprouting ; bone marrow mobilization ; Flt3 ligand Subject RIV FH - Neurology R&D Projects IAA500390902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000294904300008 DOI 10.3109/14653249.2011.575355 Annotation The aim of this study was to evaluate the effect of G-CSF and/or the Flt3 ligand on functional outcome and tissue regeneration in a rat model of spinal cord injury (SCI). Rats with a balloon-induced compression lesion were injected with G-CSF and/or Flt3 ligand to mobilize bone marrow cells. Behavioral tests, blood counts, morphometric evaluation of the white and gray matter, and histology were performed 5 weeks after SCI.Our results showed, that the mobilization of bone marrow cells by G-CSF, Flt3 ligand and particularly their combination improved the motor and sensory performance of rats with SCI, reduced glial scarring, increased axonal sprouting and spared white and gray matter in the lesion. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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