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Characterization of prolactin-releasing peptide: Binding, signaling and hormone secretion in rodent pituitary cell lines endogenously expressing its receptor

SYSNO ASEP	0359843
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Characterization of prolactin-releasing peptide: Binding, signaling and hormone secretion in rodent pituitary cell lines endogenously expressing its receptor
Author(s)	Maixnerová, Jana (UOCHB-X) Špolcová, Andrea (UOCHB-X)_{RID, ORCID} Pýchová, Miroslava (UOCHB-X) Blechová, Miroslava (UOCHB-X) Elbert, Tomáš (UOCHB-X)_{RID, ORCID} Řezáčová, M. (CZ) Železná, Blanka (UOCHB-X)_{RID, ORCID} Maletínská, Lenka (UOCHB-X)_{RID, ORCID}
Number of authors	8
Source Title	Peptides. - : Elsevier - ISSN 0196-9781 Roč. 32, č. 4 (2011), s. 811-817
Number of pages	7 s.
Language	eng - English
Country	US - United States
Keywords	PrRP ; pituitary cell lines ; food intake
Subject RIV	CC - Organic Chemistry
R&D Projects	GAP303/10/1368 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000289707300026
DOI	10.1016/j.peptides.2010.12.011
Annotation	The recently discovered prolactin-releasing peptide (PrRP) binds to the PrRP receptor and is involved in endocrine regulation and energy metabolism. However, its main physiological role is currently unknown. Two biologically active isoforms of PrRP exist: the 31 (PrRP31) and the 20 (PrRP20) amino acid forms, which both contain a C-terminal Phe amide sequence. In the present study, the PrRP receptor was immunodetected in three rodent tumor pituitary cell lines: GH3, AtT20 and RC-4B/C cells. Food intake after intracerebroventricular administration of PrRP analogs in fasted mice was followed. Both PrRP31 and PrRP20 decreased food intake, but PrRP13 did not show significant effect.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1