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Advances in Molecular Mechanisms and Pharmacology of Diabetic Complications
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SYSNO ASEP 0359624 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Glycation of proteins – their analysis and physiological aspects Author(s) Lacinová, Kateřina (FGU-C) RID
Eckhardt, Adam (FGU-C) RID, ORCID
Pataridis, Statis (FGU-C)
Sedláková, Pavla (FGU-C) RID
Mikšík, Ivan (FGU-C) RID, ORCID, SAISource Title Advances in Molecular Mechanisms and Pharmacology of Diabetic Complications. - Kerala : Transworld research network, 2010 / Stefek Milan - ISBN 978-81-7895-499-8 Pages s. 17-38 Number of pages 22 s. Number of pages 341 Language eng - English Country IN - India Keywords proteomics ; posttranslational modification ; HPLC-MS ; CE Subject RIV CE - Biochemistry CEZ AV0Z50110509 - FGU-C (2005-2011) Annotation Posttranslational non-enzymatic modifications of proteins (as well as of lipoproteins and glycoproteins) are important protein reactions, which are believed to play an important role in several physiological and pathophysiological processes, such as aging, diabetes mellitus, etc. Non-enzymatic chemical reactions that occur between an oxo-group typically stemming from reducing sugars (or arising from lipid oxidation/peroxidation) and the free amino groups of proteins/peptides lead to the formation of a plethora of still poorly characterized reaction products (the so-called Maillard reaction) Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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