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Evolution and metabolic significance of the urea cycle in photosynthetic diatoms
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SYSNO ASEP 0359538 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evolution and metabolic significance of the urea cycle in photosynthetic diatoms Author(s) Allen, A. E. (US)
Dupont, Ch. L. (US)
Oborník, Miroslav (BC-A) RID, ORCID
Horák, Aleš (BC-A) RID, ORCID
Nunes-Nesi, A. (DE)
McCrow, J. P. (US)
Zheng, H. (US)
Johnson, D. A. (US)
Hu, H. (FR)
Fernie, A. R. (DE)
Bowler, Ch. (FR)Source Title Nature. - : Palgrave Macmillan - ISSN 0028-0836
Roč. 473, č. 7346 (2011), s. 203-209Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords CARBAMOYL-PHOSPHATE SYNTHETASE ; PHAEODACTYLUM-TRICORNUTUM ; MAXIMUM-LIKELIHOOD ; PHYLOGENETIC RECONSTRUCTION ; MOLECULAR EVOLUTION ; SEQUENCE ALIGNMENT ; DIVERGENCE TIMES ; MARINE DIATOMS ; MIXED MODELS ; TREE Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA206/08/1423 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000290487200036 DOI 10.1038/nature10074 Annotation RNA-interference-mediated knockdown of a mitochondrial carbamoyl phosphate synthase impairs the response of nitrogen-limited diatoms to nitrogen addition. Intermediates in the ornithine-urea cycle are particularly depleted and both the tricarboxylic acid cycle and the glutamine synthetase/glutamate synthase cycles are linked directly with the ornithine-urea cycle. Several other metabolites are generated from this cycle by products of genes acquired from bacteria. So far, this cycle is only known for its essential role in the removal of fixed nitrogen in metazoans. In diatoms, this cycle serves as a distribution and repackaging hub for inorganic carbon and nitrogen and contributes significantly to the metabolic response of diatoms to episodic nitrogen availability. The diatomornithine-urea cycle therefore represents a key pathway for anaplerotic carbon fixation into nitrogenous compounds that are essential for diatom growth and for the contribution of diatoms to marine productivity. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
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