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Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells

SYSNO ASEP	0359477
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells
Author(s)	Šolc, Petr (UZFG-Y)_{RID, ORCID} Schultz, R. M. (US) Motlík, Jan (UZFG-Y)_{RID, ORCID}
Source Title	Molecular Human Reproduction - ISSN 1360-9947 Roč. 16, č. 9 (2010), s. 654-664
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	resumption of meiosis ; prophase I arrest ; oocyte
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GC301/09/J036 GA ČR - Czech Science Foundation (CSF)
	ME08030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50450515 - UZFG-Y (2005-2011)
UT WOS	000281535400006
DOI	10.1093/molehr/gaq034
Annotation	Mammalian oocytes are arrested at prophase I until puberty when luteinizing hormone (LH) induces resumption of meiosis of follicle-enclosed oocytes. Resumption of meiosis is tightly coupled with regulating cyclin-dependent kinase 1 (CDK1) activity. Prophase I arrest depends on inhibitory phosphorylation of CDK1 and anaphase-promoting complex-(APC-CDH1)-mediated regulation of cyclin B levels. Prophase I arrest is maintained by endogenously produced cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) that in turn phosphorylates (and activates) the nuclear kinase WEE2. In addition, PKA-mediated phosphorylation of the phosphatase CDC25B results in its cytoplasmic retention. The combined effect maintains low levels of CDK1 activity that are not sufficient to initiate resumption of meiosis.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2012

Number of the records: 1