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Hydrazone-based hydrogel hydrolytically degradable in acidic environment

SYSNO ASEP	0359454
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Hydrazone-based hydrogel hydrolytically degradable in acidic environment
Author(s)	Vetrík, Miroslav (UMCH-V)_{RID, ORCID} Přádný, Martin (UMCH-V)_RID Hrubý, Martin (UMCH-V)_{RID, ORCID} Michálek, Jiří (UMCH-V)_{RID, ORCID}
Source Title	Polymer Degradation and Stability. - : Elsevier - ISSN 0141-3910 Roč. 96, č. 5 (2011), s. 756-759
Number of pages	4 s.
Language	eng - English
Country	NL - Netherlands
Keywords	polymer ; hydrogel ; hydrazone bond
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	GAP108/10/1560 GA ČR - Czech Science Foundation (CSF)
	GPP207/10/P054 GA ČR - Czech Science Foundation (CSF)
	1M0538 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000290078200004
DOI	10.1016/j.polymdegradstab.2011.02.020
Annotation	We describe the synthesis of new crosslinker N′-{3-[2-(4-{2-[3-(methacryloylamino) propanoyl] hydrazono}cyclohexyliden)hydrazino]-3-oxopropyl}-2-methylacrylamide, which is stable at physiological pH, but is hydrolytically cleaved in acidic pH. Study of acid hydrolysis showed that the crosslinker is hydrolyzed into two N′-(3-hydrazino-3-oxopropyl)-2-methylacrylamide molecules and one 1,4-cyclohexanedione molecule. Hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with this crosslinker were prepared and their degradation rate was studied as a function of pH (in the range of pH 1.5–7.4). The hydrogel is cleaved within 8–27 days at pH between 1.5 and 6 and is stable at pH 7.4 making it promising for the construction of oesophageal stents.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2012

Number of the records: 1