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A new type of irreversibly reductively biodegradable hydrogel

SYSNO ASEP	0359453
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A new type of irreversibly reductively biodegradable hydrogel
Author(s)	Vetrík, Miroslav (UMCH-V)_{RID, ORCID} Hrubý, Martin (UMCH-V)_{RID, ORCID} Přádný, Martin (UMCH-V)_RID Michálek, Jiří (UMCH-V)_{RID, ORCID}
Source Title	Polymer Degradation and Stability. - : Elsevier - ISSN 0141-3910 Roč. 96, č. 5 (2011), s. 892-897
Number of pages	6 s.
Language	eng - English
Country	NL - Netherlands
Keywords	biodegradable hydrogel ; disulfide ; L-cysteine
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	GAP108/10/1560 GA ČR - Czech Science Foundation (CSF)
	GPP207/10/P054 GA ČR - Czech Science Foundation (CSF)
	1M0538 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000290078200021
DOI	10.1016/j.polymdegradstab.2011.01.037
Annotation	Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2012

Number of the records: 1