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Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis
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SYSNO ASEP 0359445 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis Author(s) Pravenec, Michal (FGU-C) RID, ORCID
Zídek, Václav (FGU-C) RID
Landa, Vladimír (FGU-C) RID
Šimáková, Miroslava (FGU-C) RID, ORCID
Mlejnek, Petr (FGU-C) RID, ORCID
Šilhavý, J. (CZ)
Maxová, M. (CZ)
Kazdová, L. (CZ)
Seidman, J. G. (US)
Seidman, Ch. E. (US)
Eminaga, S. (US)
Gorham, J. (US)
Wang, J. (US)
Kurtz, T. W. (US)Source Title Physiological Genomics. - : American Physiological Society - ISSN 1094-8341
Roč. 43, č. 7 (2011), s. 372-379Number of pages 8 s. Language eng - English Country US - United States Keywords transgenic rat ; adipose tissue ; insulin resistance ; autocrine effects Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects ME08006 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAA500110805 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) NS9759 GA MZd - Ministry of Health (MZ) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000289408400006 DOI 10.1152/physiolgenomics.00112.2010 Annotation We investigated potential autocrine effects of resistin on lipid and glucose metabolism in 2- and 16-mo-old transgenic spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin under control of the aP2 promoter. Our results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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