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DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei

SYSNO ASEP	0359433
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei
Author(s)	Richterová, Lenka (BC-A) Vávrová, Zuzana (BC-A) Lukeš, Julius (BC-A)_{RID, ORCID}
Source Title	Experimental Parasitology. - : Elsevier - ISSN 0014-4894 Roč. 127, č. 1 (2011), 300-303
Number of pages	4 s.
Language	eng - English
Country	US - United States
Keywords	Trypanosoma ; Mitochondrial translation ; RNA helicase ; Cytochrome c oxidase ; Mitochondrion
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GA204/09/1667 GA ČR - Czech Science Foundation (CSF)
	LC07032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	2B06129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000286486800046
DOI	10.1016/j.exppara.2010.06.036
Annotation	DEAD-box RNA helicase, a putative subunit of the mitochondrial ribosome of Trypanosoma brucei, has been down-regulated in the procyclic and bloodstream stage by RNA interference. Although ablation of the transcript leads to a week growth phenotype in the procyclic cells, the protein does not seem to be essential for mitochondrial translation under standard cultivation conditions, as shown by an assay that allows visualization of the de novo synthesized proteins. Furthermore, we show that synthesis of cytochrome c oxidase subunit I and cytochrome b does not occur in the mitochondrion of the bloodstream stage.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2012

Number of the records: 1