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Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi

SYSNO ASEP	0359409
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi
Author(s)	Paris, Zdeněk (BC-A)_RID Hashimi, Hassan (BC-A)_{RID, ORCID} Lun, Sijia (BC-A) Alfonzo, J. D. (US) Lukeš, Julius (BC-A)_{RID, ORCID}
Source Title	Molecular and Biochemical Parasitology. - : Elsevier - ISSN 0166-6851 Roč. 176, č. 2 (2011), 116-120
Number of pages	5 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Trypanosoma ; tRNA ; Protein import ; Mitochondrion ; Kinetoplast
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GA204/09/1667 GA ČR - Czech Science Foundation (CSF)
	LC07032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000288629800007
DOI	10.1016/j.molbiopara.2010.12.010
Annotation	Trypanosoma brucei brucei has two distinct developmental stages, the procyclic stage in the insect and the bloodstream stage in the mammalian host. The significance of each developmental stage is punctuated by specific changes in metabolism. In the insect, T. b. brucei is strictly dependent on mitochondrial function and thus respiration to generate the bulk of its ATP, whereas in the mammalian host it relies heavily on glycolysis. Peculiarly, akinetoplastic strains of T. b. evansi that lack mitochondrial DNA do exist in the wild and are developmentally locked in the glycolysis-dependent bloodstream stage. Using RNAi we show that two mitochondrion-imported proteins, mitochondrial RNA polymerase and guide RNA associated protein 1, are still imported into the nucleic acids-lacking organelle of T. b. evansi, making the need for these proteins futile.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2012

Number of the records: 1