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Activities of Different Classes of Acyclic Nucleoside Phosphonates against BK Virus in Primary Human Renal Cells
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SYSNO ASEP 0359402 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Activities of Different Classes of Acyclic Nucleoside Phosphonates against BK Virus in Primary Human Renal Cells Author(s) Topalis, D. (BE)
Lebeau, I. (BE)
Krečmerová, Marcela (UOCHB-X) RID, ORCID
Andrei, G. (BE)
Snoeck, R. (BE)Number of authors 5 Source Title Antimicrobial Agents and Chemotherapy. - : American Society for Microbiology - ISSN 0066-4804
Roč. 55, č. 5 (2011), s. 1961-1967Number of pages 7 s. Language eng - English Country US - United States Keywords polyomavirus ; BK virus ; nephropathy ; acyclic nucleoside phosphonates ; HPMP-5-azaC Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000290019200018 DOI 10.1128/AAC.01809-10 Annotation Evaluation of three different classes of acyclic nucleoside phosphonates for their activities against BK virus replication was performed. HPMPC, HPMP-5-azaC, its cyclic form and HDE ester of its cyclic form were found the most selective inhibitors of BKV replication in primary human renal cells. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2012
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