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Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles
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SYSNO ASEP 0359268 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles Author(s) Volkov, E. M. (RU)
Nurullin, L. F. (RU)
Volkov, M. E. (RU)
Nikolsky, E. E. (RU)
Vyskočil, František (FGU-C) RIDSource Title Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. - : Elsevier - ISSN 1095-6433
Roč. 158, č. 4 (2011), s. 520-524Number of pages 5 s. Language eng - English Country US - United States Keywords GABA ; acetylcholine ; atropine Subject RIV ED - Physiology R&D Projects IAA500110905 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA202/09/0806 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000288640700022 DOI 10.1016/j.cbpa.2010.12.016 Annotation This work was aimed to identify the action of several ion channel and pump inhibitors as well as nicotinic, GABAergic, purinergic and serotoninergic drugs on the resting membrane potential (RMP) and assess the role of cholinergic and GABAergic sensitivity in earthworm muscle electrogenesis. . The long-term application of CCh depolarizes the RMP primarily by inhibiting the Na+/K+-ATPase. The muscle membrane also contains A and B type GABA binding sites, the activation of which increases the RMP at the expense of increasing the action of ouabain- and Cl- -sensitive electrogenic pumps Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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