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The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases

SYSNO ASEP	0359135
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases
Author(s)	Kovačková, Soňa (UOCHB-X) Dračínský, Martin (UOCHB-X)_{RID, ORCID} Rejman, Dominik (UOCHB-X)_{RID, ORCID}
Number of authors	3
Source Title	Tetrahedron. - : Elsevier - ISSN 0040-4020 Roč. 67, č. 7 (2011), s. 1485-1500
Number of pages	16 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	piperidine derivatives ; nucleoside analogs ; nucleobase ; proline
Subject RIV	CC - Organic Chemistry
R&D Projects	2B06065 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	NR9138 GA MZd - Ministry of Health (MZ)
	LC06077 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000287340600013
DOI	10.1016/j.tet.2010.12.029
Annotation	This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1