Number of the records: 1

Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells

SYSNO ASEP	0359013
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells
Author(s)	Procházková, Jiřina (BFU-R)_{RID, ORCID} Kozubík, Alois (BFU-R)_{RID, ORCID} Machala, M. (CZ) Vondráček, Jan (BFU-R)_{RID, ORCID}
Number of authors	4
Source Title	Toxicology. - : Elsevier - ISSN 0300-483X Roč. 279, 1-3 (2011), s. 146-154
Number of pages	9 s.
Language	eng - English
Country	NL - Netherlands
Keywords	indirubin ; aryl hydrocarbon receptor ; plakoglobin
Subject RIV	BO - Biophysics
R&D Projects	GA524/06/0517 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000287109900018
DOI	10.1016/j.tox.2010.10.003
Annotation	Effects of indirubin, a putative novel ligand of aryl hydrocarbon receptor, had been tested in an in vitro model of rat oval cells, and compared with the effects of model toxic ligand, TCDD. We observed dose-sependent differences in indirubin action on AhR activation and on expression of selected genes known to be regulated by AhR/ARNT signaling pathway.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2012

Number of the records: 1