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Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles

SYSNO ASEP	0358984
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles
Author(s)	Kačenka, M. (CZ) Kaman, Ondřej (FZU-D)_{RID, ORCID} Kotek, J. (CZ) Falteisek, L. (CZ) Černý, J. (CZ) Jirák, D. (CZ) Herynek, V. (CZ) Zacharovová, K. (CZ) Berková, A. (CZ) Jendelová, Pavla (UEM-P)_{RID, ORCID} Kupčík, Jaroslav (UCHP-M)_{RID, ORCID, SAI} Pollert, Emil (FZU-D) Veverka, Pavel (FZU-D)_{RID, ORCID} Lukeš, I. (CZ)
Source Title	Journal of Materials Chemistry. - : ROYAL SOC CHEMISTRY - ISSN 0959-9428 Roč. 21, č. 1 (2011), s. 157-164
Number of pages	8 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	cellular labelling ; dual probe ; magnetic nanoparticles ; MRI ; silica coating
Subject RIV	BM - Solid Matter Physics ; Magnetism
R&D Projects	KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z10100521 - FZU-D (2005-2011)
	AV0Z50390703 - UEM-P (2007-2013)
	AV0Z40720504 - UCHP-M (2005-2011)
UT WOS	000285067300019
DOI	10.1039/c0jm01258k
Annotation	The present study reveals the potential of magnetic nanoparticles based on the La0.75Sr0.25MnO3 perovskite manganite for MRI. Moreover, it describes the development of the dual imaging probe where the magnetic cores are combined with a fluorescent moiety while the improved colloidal stability is achieved by a two-ply silica shell. At first, the magnetic cores of La0.75Sr0.25MnO3 are coated with a hybrid silica layer, comprising a covalently attached fluorescein moiety that is subsequently covered by a pure silica layer providing the enhanced stability. Viability tests show that the complete particles are suitable for biological studies and the internalization occurs in different cell types. Further experiments prove no fatal interference with the vitality. Relaxometric measurements confirm high spin–spin relaxivities and visualisation of in vitro labeled pancreatic islets by MRI is successfully tested.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2012

Number of the records: 1