Number of the records: 1

A “Cute” Desensitization of TRPV1

SYSNO ASEP	0358917
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A “Cute” Desensitization of TRPV1
Author(s)	Touška, Filip (FGU-C)_{ORCID, SAI} Maršáková, Lenka (FGU-C)_RID Teisinger, Jan (FGU-C)_RID Vlachová, Viktorie (FGU-C)_{RID, ORCID, SAI}
Source Title	Current Pharmaceutical Biotechnology - ISSN 1389-2010 Roč. 12, č. 1 (2011), s. 122-129
Number of pages	8 s.
Language	eng - English
Country	NL - Netherlands
Keywords	capsaicin ; analgesia ; vanilloid receptor
Subject RIV	FH - Neurology
R&D Projects	GA305/09/0081 GA ČR - Czech Science Foundation (CSF)
	GAP301/10/1159 GA ČR - Czech Science Foundation (CSF)
	IAA600110701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	1M0517 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000286589900014
DOI	10.2174/138920111793937826
Annotation	Upon stimulation, the calcium influx via the vanilloid TRPV1 channels acutely desensitizes the channels themselves, which, from the cellular point of view, represents a feedback mechanism protecting the nociceptive neuron from toxic calcium overload. This review attempts to cover historical aspects of research into this process, tries to highlight some new challenging thoughts on the important phenomenon of TRPV1 desensitization and focuses on the putative molecular mechanisms that are thought to account for the acute phase of this process (‘acute desensitization’)
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2012

Number of the records: 1